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KMID : 0043320120350030517
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Archives of Pharmacal Research
2012 Volume.35 No. 3 p.517 ~ p.522
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Preparation and determination of optical purity of γ-lysine modified peptide nucleic acid analogues
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Huang Hu
Joe Goon-Ho
Choi Sung-Rok
Kim Su-Nam
Kim Yong-Tae
Pak Hwang-Siek
Kim Sung-Kee
Hong Joon-Hee
Han Hyo-Kyung
Kang Jong-Seong
Lee Won-Jae
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Abstract
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Peptide nucleic acids (PNAs) are DNA analogues in which the nucleic acid backbone is replaced by a pseudopeptide backbone and nucleobases are attached to the backbone by methylene carbonyl linkers. -Carbon modification of the PNA structure allows monomers, and subsequently oligomers, with improved properties to be obtained. In this study, we report the convenient synthesis of γ-lysine-modified PNA monomers for pyrimidine bases (thymine and cytosine) with high optical purity (> 99.5%) and direct enantiomer separation of γ-lysine-modified PNA analogs, using chiral HPLC to determine the optical purity.
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KEYWORD
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Peptide nucleic acid, γ-Lysine modified PNA, Optical purity
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